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Related Experiment Video

Updated: May 22, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Canine left ventricle electromechanical behavior under different pacing modes.

Thanh-Thuy Vo Thang¹, Bernard Thibault, Vincent Finnerty

¹Department of Nuclear Medicine, Montreal Heart Institute, University of Montreal, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing

|May 15, 2012

Summary

Biventricular pacing in heart failure models reduced electromechanical delay, a key factor in cardiac resynchronization therapy. This study quantines electrical and mechanical coupling to improve patient outcomes.

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Last Updated: May 22, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Area of Science:

Cardiology
Biomedical Engineering
Medical Imaging

Background:

Cardiac resynchronization therapy (CRT) can improve survival and quality of life in heart failure patients with left ventricular (LV) dyssynchrony.
Few studies have explored macroscopic activation-contraction coupling, focusing instead on electrical or mechanical determinants.

Purpose of the Study:

To characterize LV electromechanical behavior and pacing response in a heart failure model.
To investigate the effects of different pacing modes on electrical activation and mechanical contraction.

Main Methods:

Utilized 3D electroanatomic non-contact mapping and blood pool SPECT in 12 dogs with pacing-induced dilated cardiomyopathy.
Registered surfaces from both imaging modalities to analyze electrical signals and endocardial wall displacement.
Quantified activation duration, electromechanical delay, and LV ejection fraction (LVEF) for various pacing modes.

Main Results:

Rapid pacing reduced LVEF to 20.9% and prolonged QRS duration (79 ms).
Biventricular pacing did not change QRS duration (88.5 ms), while single-site pacing prolonged it (113.3 ms RV, 111.6 ms LV).
Electromechanical delay increased with single-site pacing but not with biventricular pacing (162.4 ms).

Conclusions:

Combined electroanatomic mapping and SPECT imaging enabled quantification of electromechanical parameters.
Pacing modes altered electromechanical delay, with biventricular pacing significantly decreasing it.
Biventricular pacing shows potential for improving electromechanical synchrony in heart failure models.