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Updated: May 22, 2026

Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models
10:42

Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models

Published on: October 22, 2012

Targeting NADPH oxidases for the treatment of cancer and inflammation

Michael Y Bonner1, Jack L Arbiser

  • 1Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Cellular and Molecular Life Sciences : CMLS
|May 15, 2012
PubMed

Insights

NADPH oxidases (nox) generate reactive oxygen species. This review explores targeting nox enzymes with inhibitors for inflammatory and malignant disorders, discussing clinical experiences.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • NADPH oxidases (nox) are enzymes utilizing molecular oxygen to produce hydrogen peroxide and superoxide.
  • These reactive species have crucial physiological roles, but their dysregulation is implicated in disease.
  • The nox family (Nox1-5, Duox1-2) exhibits complex regulation, subunit composition, localization, and expression patterns.

Purpose of the Study:

  • To review the targeting of NADPH oxidases in disease states.
  • To discuss specific inflammatory and malignant disorders amenable to nox inhibition.
  • To summarize clinical experiences with nox inhibitors.

Main Methods:

  • Literature review of NADPH oxidase function and regulation.
  • Analysis of studies investigating nox inhibitors in disease models.
  • Compilation of clinical trial data and case reports on nox inhibitor use.

Main Results:

  • NADPH oxidases play roles in various inflammatory and malignant conditions.
  • The complexity of the nox family allows for specific therapeutic targeting.
  • Clinical data on nox inhibitors, while emerging, shows potential.

Conclusions:

  • NADPH oxidases represent promising therapeutic targets for inflammatory and malignant diseases.
  • Further research and clinical trials are needed to optimize nox inhibitor therapies.
  • Targeting nox enzymes offers a potential strategy for novel disease treatments.

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