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Related Concept Videos

Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell

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Related Experiment Video

Updated: May 22, 2026

X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
12:57

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Published on: December 9, 2022

[Progress in prolactin receptor research].

Dun-Yong Tan1, Xiang-Ping Peng

  • 1Jishou University College of Medicine, Jishou 416000, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Prolactin (PRL) and its receptor (PRLR) play crucial roles in numerous biological functions. Aberrant PRLR signaling is linked to cancer, with antagonists showing therapeutic promise.

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Last Updated: May 22, 2026

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In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues

Published on: March 21, 2017

Area of Science:

  • Endocrinology and molecular biology
  • Cell signaling and receptor biology

Context:

  • Prolactin (PRL) is a hormone secreted by the anterior pituitary and extra-pituitary tissues.
  • PRL, growth hormone (GH), and placental lactogens (PL) evolved from a common ancestral gene.
  • PRL exerts its functions via endocrine, paracrine, and autocrine signaling pathways.

Purpose:

  • To review the structure and function of prolactin receptors (PRLRs).
  • To highlight the role of PRLR in cancer pathogenesis, progression, and prognosis.
  • To discuss the therapeutic potential of PRLR antagonists.

Summary:

  • Prolactin receptors (PRLRs) exist in multiple isoforms (long, intermediate, short) derived from alternative splicing of a common gene.
  • Despite shared extracellular and transmembrane domains, PRLR isoforms differ in their intracellular domains, mediating distinct cellular functions.
  • Abnormalities in PRLR are implicated in the development and progression of various cancers, notably breast cancer.

Impact:

  • Understanding PRLR isoforms and their functions is crucial for deciphering complex biological processes.
  • Targeting PRLR with antagonists presents a promising therapeutic strategy for managing PRLR-associated cancers.
  • This research provides insights into hormone receptor signaling and its implications in disease treatment.