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Usefulness of parathyroid hormone as a predictor of heart failure with preserved ejection fraction

Hakan Altay1, Ali Zorlu, Muhammet Bilgi

  • 1Department of Cardiology, Baskent University Faculty of Medicine, Adana, Turkey. sakaltay@yahoo.com

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|May 16, 2012
PubMed

Insights

Parathyroid hormone (PTH) levels correlate with advanced heart failure with preserved ejection fraction (HF-PEF). Measuring PTH offers valuable insights for diagnosing and predicting HF-PEF in outpatients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Heart failure with preserved ejection fraction (HF-PEF) is a growing clinical challenge.
  • The role of parathyroid hormone (PTH) in HF-PEF pathophysiology requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between serum parathyroid hormone (PTH) levels and HF-PEF in an outpatient cohort.
  • To identify PTH as a potential diagnostic or prognostic marker for HF-PEF.

Main Methods:

  • One hundred outpatients with symptomatic HF and preserved left ventricular ejection fraction were enrolled.
  • Echocardiography was performed to assess diastolic function.
  • Serum intact PTH and brain natriuretic peptide (BNP) levels were measured.

Main Results:

  • Significant correlations were observed between PTH levels and predictors of advanced HF-PEF (p < 0.05).
  • Serum PTH level and left atrium diameter emerged as independent predictors of diastolic heart failure (DHF).

Conclusions:

  • Serum PTH measurement provides complementary information for the diagnosis of HF-PEF.
  • PTH levels may aid in the prognostic assessment of patients with HF-PEF.
Abstract

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