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Updated: May 22, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Efficacy of fibrinogen/thrombin-coated equine collagen patch in controlling lymphatic leaks

Vladimiro L Vida1, Massimo A Padalino, Elisa Barzon

  • 1Department of Cardiac, Thoracic and Vascular Surgery, University of Padua Medical School, Padua, Italy. vladimirovida@yahoo.it

Journal of Cardiac Surgery
|May 16, 2012
PubMed

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.