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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

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Updated: May 22, 2026

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

Developing phytoestrogens for breast cancer prevention.

Mandy M Liu1, Ying Huang, Jeffrey Wang

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.

Anti-Cancer Agents in Medicinal Chemistry
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Phytoestrogens (PEs) show potential for breast cancer chemoprevention through mechanisms like estrogen receptor modulation. Ensuring product quality and robust clinical study design are crucial for their development.

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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

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Published on: March 17, 2016

Area of Science:

  • Oncology
  • Pharmacology
  • Nutritional Science

Background:

  • Breast cancer is a leading cause of cancer deaths in women.
  • Phytoestrogens (PEs) are plant compounds with estrogen-like structures offering potential breast cancer chemoprevention.
  • PEs encompass isoflavones, lignans, stilbenes, and coumestans, found in various foods and herbs.

Purpose of the Study:

  • To explore the potential of phytoestrogens (PEs) as a breast cancer chemoprevention strategy.
  • To review the anti-cancer mechanisms of PEs, including estrogen receptor modulation and anti-angiogenesis.
  • To highlight the importance of quality control in PEs for clinical application.

Main Methods:

  • Literature review of phytoestrogens and their role in cancer research.
  • Analysis of PEs' anti-cancer activities and mechanisms of action.
  • Discussion of key examples like genistein, daidzein, and resveratrol.

Main Results:

  • Phytoestrogens exhibit anti-cancer properties through multiple biological pathways.
  • Estrogen receptor modulation, aromatase inhibition, and anti-angiogenesis are key mechanisms.
  • Specific PEs like genistein and resveratrol have demonstrated therapeutic potential.

Conclusions:

  • Phytoestrogens represent a promising avenue for breast cancer chemoprevention.
  • Rigorous quality control in manufacturing and clinical trial design is essential for efficacy.
  • Further research is needed to optimize the clinical use of PEs in breast cancer management.