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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Miscibility analysis of particulate solid dispersions prepared by electrospray deposition
1National Institute for Materials Science, International Center for Materials Nanoarchitectonics, Biomaterials Unit, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. kawakami.kohsaku@nims.go.jp
International Journal of Pharmaceutics
|May 16, 2012
Summary
Electrospray deposition creates solid dispersions with tunable particle sizes. Drug miscibility with polymers influences phase separation and physical characteristics in particulate formulations.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Solid dispersions enhance drug solubility and bioavailability.
- Electrospray deposition offers precise control over particulate formulation characteristics.
Purpose of the Study:
- To investigate the physical characteristics of solid dispersions prepared by electrospray deposition.
- To explore the influence of drug-excipient miscibility on solid dispersion properties.
Main Methods:
- Electrospray deposition of carbamazepine and prednisolone with poly(vinyl pyrrolidone) and Eudragit.
- Characterization of particle size, drug loading, and phase behavior.
- Analysis of thermodynamic and dynamic factors affecting phase separation.
Main Results:
- Particle size was controllable, ranging from micrometers down to 400 nm, influenced by solution concentration, flow rate, and conductivity.
- Carbamazepine showed homogeneous loading up to 40% before crystalline phase separation.
- Prednisolone exhibited higher homogeneous loading (up to 60%) and maintained an amorphous state upon excess addition, unlike carbamazepine.
Conclusions:
- Electrospray parameters significantly impact particle size and morphology.
- Drug-excipient miscibility and molecular properties play a crucial role in determining the phase behavior and physical state of solid dispersions.
- Both thermodynamic and dynamic factors govern drug phase separation during electrospray deposition.
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