[5-Fluorouracil and trabeculectomy. A trial of low doses]

Postoperative subconjonctival 5-Fluorouracil (5 FU) may enhance the surgical outcome of trabeculectomies in eyes at high risk of operative failure. 23 patients who received postoperative low doses of subconjonctival 5 Fluorouracil (5 FU) have been studied with a mean follow-up of 10 months. Our indications were: risk factors for a trabeculectomy; postoperative pressure remaining high or absence of filtering bleb. The results were: 42% of complete success (IOP less than 21 mmHg without addition therapy); 29% of qualified success (IOP less than 25 mmHg with additional therapy, or 21 mmHg less than IOP less than 25 mmHg without therapy); 29% of failure. The most frequent complications are corneal, but healed within a short period. The efficacity of the drug remains even with low doses, and with less complications.