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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Meiosis II01:57

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...

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Related Experiment Video

Updated: May 22, 2026

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

In vitro oocyte maturation: current status.

Daniela Nogueira1, Jean Clair Sadeu, Jacques Montagut

  • 1Laboratoire de Biologie de la Reproduction - IFREARES, Clinique Saint Jean Languedoc, Toulouse, France. daniela_nogueira@yahoo.com

Seminars in Reproductive Medicine
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

In vitro maturation (IVM) offers a patient-friendly alternative for oocyte retrieval in assisted reproduction. Optimized IVM shows promise for infertile patients and oocyte donation, though further research is needed for routine clinical use.

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Last Updated: May 22, 2026

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Functional Manipulation of Maternal Gene Products Using In Vitro Oocyte Maturation in Zebrafish

Published on: April 22, 2017

Area of Science:

  • Assisted Reproduction Technologies
  • Reproductive Medicine
  • Oocyte Biology

Background:

  • In vitro maturation (IVM) is increasingly recognized for its clinical applications in assisted reproduction.
  • Current IVM practices, particularly 'rescue IVM,' often yield unsatisfactory results compared to conventional in vitro fertilization (IVF).
  • The distinct biological processes and clinical goals of true IVM differ significantly from rescue IVM.

Purpose of the Study:

  • To review the current landscape of IVM technology in assisted reproduction.
  • To evaluate the clinical outcomes and patient selection criteria for IVM.
  • To highlight the importance of laboratory parameters and optimal culture conditions for IVM success.

Main Methods:

  • Review of approximately 25 peer-reviewed articles on IVM published over the past decade.
  • Analysis of clinical approaches and patient populations benefiting from IVM.
  • Assessment of existing data on the safety and efficacy of IVM.

Main Results:

  • Sporadic case reports and small sample sizes characterize current IVM literature, leading to inconclusive outcomes.
  • Variable results highlight the need for improved patient selection and standardized protocols.
  • Existing data suggest IVM is a safe procedure, with potential for optimization.

Conclusions:

  • IVM presents a viable, patient-friendly alternative to conventional IVF, especially for high-risk patients and oocyte donation.
  • Optimization of laboratory parameters is crucial for improving IVM success rates.
  • Further research with larger sample sizes is necessary to establish IVM for routine clinical application.