Related Experiment Video

Updated: May 22, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
05:21

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection

Published on: August 14, 2019

Low rates of influenza immunization in young children under Ontario's universal influenza immunization program

Michael A Campitelli1, Miho Inoue, Andrew J Calzavara

  • 1Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5 Canada.

Pediatrics
|May 16, 2012
PubMed

Insights

Influenza vaccine coverage for young children in Ontario remained low between 2002-2009, despite a universal immunization program. Key predictors for vaccination included maternal immunization and pediatrician care, while social disadvantage was linked to non-vaccination.

Area of Science:

  • Pediatric Public Health
  • Vaccinology
  • Health Services Research

Background:

  • Universal influenza immunization programs aim to increase vaccine uptake in pediatric populations.
  • Assessing vaccine coverage and its predictors is crucial for public health strategy development.

Purpose of the Study:

  • To evaluate physician-administered influenza vaccine coverage in children aged 6 to 23 months in Ontario from 2002 to 2009.
  • To identify factors associated with influenza vaccination status in this age group.

Main Methods:

  • Retrospective cohort study using linked hospital and physician billing records in Ontario.
  • Infants born between April 2002 and March 2008 were tracked for immunization status.
  • Generalized linear mixed models were used to analyze predictors of vaccination.

Main Results:

  • Influenza immunization coverage was low, starting at 1% and fluctuating between 4-9% during the study period.
  • Children with chronic conditions, low birth weight, maternal influenza immunization, and pediatrician care were more likely to be vaccinated.
  • Social disadvantage was associated with lower vaccination rates.

Conclusions:

  • Despite a universal program, influenza vaccine coverage in young children in Ontario is suboptimal.
  • Interventions should focus on engaging both healthcare providers and families to improve vaccination rates.
Abstract

More Related Videos

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers06:34

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes08:52

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes

Published on: July 26, 2019

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...