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Related Concept Videos

Pancreas01:19

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...

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Related Experiment Video

Updated: May 22, 2026

A System for ex vivo Culturing of Embryonic Pancreas
10:51

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Deconstructing pancreas developmental biology.

Cecil M Benitez1, William R Goodyer, Seung K Kim

  • 1Department of Developmental Biology, Stanford University School of Medicine, California 94305-5329, USA.

Cold Spring Harbor Perspectives in Biology
|May 17, 2012
PubMed
Summary
This summary is machine-generated.

Understanding pancreas development is crucial due to rising diabetes mellitus and adenocarcinoma. Recent research reveals pancreatic cell plasticity and interconversion, advancing organogenesis insights.

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Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
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Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

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Related Experiment Videos

Last Updated: May 22, 2026

A System for ex vivo Culturing of Embryonic Pancreas
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Published on: August 27, 2012

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

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Published on: June 2, 2018

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
05:38

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

Area of Science:

  • Developmental biology
  • Endocrinology
  • Gastroenterology

Background:

  • Pancreatic diseases like diabetes mellitus and adenocarcinoma are increasingly prevalent.
  • The pancreas is vital for endocrine and exocrine functions, regulated by epithelial cells.
  • Understanding pancreas development is key to addressing these diseases.

Purpose of the Study:

  • To review recent advancements in understanding pancreas organogenesis.
  • To highlight novel mechanisms governing pancreatic cell development and plasticity.
  • To integrate classical and modern techniques for dissecting pancreas development.

Main Methods:

  • Classical cell biology and genetic analysis.
  • Lineage tracing and embryological investigations.
  • Modern techniques: epigenetic analysis, time-lapse imaging, flow cytometry.

Main Results:

  • Recent discoveries illuminate mechanisms of pancreatic cell birth, differentiation, and maturation.
  • Studies reveal unexpected flexibility and fate interconversion in pancreatic cell subsets.
  • Integration of diverse methods provides a comprehensive view of development.

Conclusions:

  • Pancreas development is a complex process involving intricate regulatory mechanisms.
  • Cellular plasticity is a key feature of pancreatic development.
  • Combining classical and modern approaches offers powerful tools to study pancreas organogenesis.