Diagnosis of early embryonic demise by endovaginal sonography

To determine the embryonic size at which cardiac activity is always seen in a normal early pregnancy, 398 endovaginal sonograms were evaluated in which the gestational sac contained a yolk sac and/or embryo of less than or equal to 12 mm in crown-rump length (CRL). In the 99 sonograms in which there was a yolk sac but no identifiable embryo, cardiac activity was absent in 75; 58 of these pregnancies progressed normally. Of the 299 sonograms where there was an identifiable embryo with CRL less than or equal to 12 mm, cardiac activity was absent in 31; 29 of these were proven to be failed pregnancies. In two cases the pregnancy progressed normally; the CRL was 2 mm in one case and 4 mm in the other. We conclude that once an embryo is seen by endovaginal sonography, the absence of cardiac activity usually indicates embryonic demise. However, when cardiac activity is absent, one should refrain from definitively diagnosing embryonic demise, based on a single sonogram, if the CRL is less than 5 mm.