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Updated: May 22, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4-[2-(Benzyl-amino)-phen-yl]-2,6-dimethyl-quinoline N-oxide
Mario Geffe1, Dieter Schollmeyer, Heiner Detert
1University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.
Abstract:
The title compound, C(24)H(22)N(2)O, was obtained in a two-step procedure from the corresponding 4-(2-iodo-phen-yl)quinoline. The quinoline system is approximately planar [maximum deviation from the least-squares plane = 0.021 (2) Å]. The planes of the quinoline system and the phenyl ring subtend a dihedral angle of 78.08 (8)°. In the crystal, pairs of mol-ecules are connected via a center of symmetry and linked by a pair of angular N-H⋯O hydrogen bond. These dimers form columns oriented along the c axis.
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