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Published on: May 6, 2018
Proteinuria and clinical outcomes after ischemic stroke
1Cerebrovascular and Neurology Center, National Hospital Organization Fukuoka Higashi Medical Center, Fukuoka, Japan.
Chronic kidney disease (CKD) significantly worsens outcomes for acute ischemic stroke patients. Proteinuria is a key risk factor for neurological decline, mortality, and poor function, while eGFR may not be directly related.
Area of Science:
- Nephrology
- Neurology
- Clinical Medicine
Background:
- Chronic kidney disease (CKD) impacts numerous clinical outcomes.
- The specific effects of CKD on acute ischemic stroke (AIS) patients remain unclear.
- Understanding these impacts is crucial for improving stroke care.
Purpose of the Study:
- To investigate the influence of CKD and its components (proteinuria, low eGFR) on clinical outcomes after AIS.
- To determine if proteinuria or reduced eGFR are independent predictors of adverse outcomes in AIS patients.
Main Methods:
- Analysis of 3,778 first-ever ischemic stroke patients from the Fukuoka Stroke Registry.
- CKD defined by proteinuria or eGFR <60 mL/min/m(2).
- Outcomes assessed: neurologic deterioration, in-hospital mortality, and poor functional outcome using logistic regression.
Main Results:
- CKD prevalence was 34.9% (1,320 patients).
- CKD patients showed significantly higher risks of neurologic deterioration, mortality, and poor functional outcome (p <0.001).
- Higher proteinuria correlated with increased risk for all outcomes (p <0.001), but eGFR did not show a clear association.
Conclusions:
- CKD is a significant predictor of poor outcomes in acute ischemic stroke.
- Proteinuria independently increases risks of neurologic deterioration, mortality, and poor functional outcome.
- eGFR levels may not be directly associated with these adverse outcomes in AIS patients.
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