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Published on: February 9, 2021
Association between osteoporosis and urinary calculus: evidence from a population-based study
J J Keller1, C-C Lin, J-H Kang
1School of Public Health, Taipei Medical University, 250 Wu-Hsing St, Taipei, 110, Taiwan.
Summary
Osteoporosis is linked to a history of urinary calculus (UC), a common condition. This study found a significant association between prior UC and osteoporosis, regardless of stone location.
Area of Science:
- Bone health and metabolic disorders
- Urology and nephrology
- Epidemiology and public health
Background:
- Urinary calculus (UC) is a known risk factor for osteoporotic fractures.
- Previous research has not directly examined the link between UC and osteoporosis.
- This study addresses this gap by investigating the association in a Taiwanese population.
Purpose of the Study:
- To determine if a history of urinary calculus (UC) is associated with osteoporosis.
- To analyze this association using a large, population-based dataset.
- To explore if stone location influences the association.
Main Methods:
- A population-based case-control study was conducted in Taiwan.
- 39,840 osteoporosis cases (≥40 years) were identified and matched with 79,680 controls.
- Conditional logistic regression was used to calculate the odds ratio (OR) for prior UC.
Main Results:
- An association was found between osteoporosis and prior UC (adjusted OR = 1.66).
- This association remained significant across different urinary stone locations (kidney, ureter, bladder).
- Adjusted ORs for specific stone locations ranged from 1.59 to 1.71.
Conclusions:
- A significant association exists between osteoporosis and a history of urinary calculus (UC).
- The findings are consistent regardless of the urinary stone's location.
- This suggests a potential shared pathway or risk factor linking UC and osteoporosis.
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