Related Experiment Video
Updated: May 22, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Odontogenic myxomas are not associated with GNAS1 mutations
Reinhard E Friedrich1, Hanna A Scheuer, Alexandre T Assaf
1Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr. 52, D-20246 Hamburg, Germany. rfriedrich@uke.de
Unlabelled:
Myxomas are rare tumors of unknown aetiology arising in the jaws. Myxomas are also diagnosed in soft tissues. Recent reports on Gs alpha subunit gene (GNAS1) mutations occasionally being identified in soft tissue myxomas in non-syndromatic patients and the effects of myxoma on bone in variants of fibrous dysplasia led us to re-examine the putative role of GNAS1 mutations in odontogenic myxoma.
Material And Methods:
Seven biopsies from patients with confirmed diagnosis of odontogenic myxoma and two cases of fibrous dyplasia of the jaw were investigated for GNAS1 mutations by polymerase chain reaction.
Results:
Although GNAS1 was mutated in cases of fibrous dysplasia, no GNAS1 mutations were detected in odontogenic myxomas.
Conclusion:
The development of odontogenic myxoma is independent of mutations of GNAS1.
Related Concept Videos
The Ras Gene
Ras is a superfamily...
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Abnormal Proliferation
lncRNA - Long Non-coding RNAs
Pleiotropy

