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Disorders of calcium and phosphorus homeostasis

J M Gertner1

  • 1Department of Pediatrics, New York Hospital-Cornell Medical Center, New York.

Pediatric Clinics of North America
|December 1, 1990
PubMed

Insights

This review covers calcium and phosphorus physiology, focusing on how vitamin D disorders impact bone health, especially in children. It also discusses metabolic bone disease in premature infants.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Endocrinology

Background:

  • Calcium and phosphorus are essential minerals, ranking fifth and sixth in body abundance.
  • These elements are crucial for numerous physiological functions, with the skeleton being their primary reservoir.
  • Disruptions in their metabolism, particularly in children, can lead to significant skeletal disorders.

Purpose of the Study:

  • To review the fundamental physiology of calcium and phosphorus.
  • To examine the skeletal and systemic effects of vitamin D nutrition and metabolism disorders.
  • To discuss metabolic bone disease specifically in the context of prematurity.

Main Methods:

  • Literature review of calcium and phosphorus physiology.
  • Analysis of the impact of vitamin D on mineral metabolism.
  • Examination of metabolic bone disease in premature infants.

Main Results:

  • Calcium and phosphorus are vital for physiological systems and skeletal integrity.
  • Vitamin D disorders significantly affect bone health and systemic physiology.
  • Metabolic bone disease is a critical concern in premature infants.

Conclusions:

  • Understanding calcium, phosphorus, and vitamin D metabolism is key to preventing bone disorders.
  • Early identification and management of these metabolic issues are crucial for child health.
  • Metabolic bone disease in prematurity requires specialized attention and care.

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