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Related Concept Videos

Osmoregulation in Fishes02:32

Osmoregulation in Fishes

When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
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Published on: October 27, 2017

Exploring androgen-regulated pathways in teleost fish using transcriptomics and proteomics.

Christopher J Martyniuk1, Nancy D Denslow

  • 1Canadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, NB E2L 4L5, Canada. cmartyn@unb.ca

Integrative and Comparative Biology
|May 19, 2012
PubMed
Summary
This summary is machine-generated.

Aquatic pollutants disrupt fish androgen signaling. Omics studies reveal common cellular responses across species, including lipid metabolism and immune responses, and identify androgen-regulated protein networks.

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Area of Science:

  • Environmental toxicology
  • Molecular biology
  • Fish ecotoxicology

Background:

  • Aquatic environments face pollutants disrupting fish androgen signaling.
  • Omics technologies are crucial for understanding molecular mechanisms of androgen receptor agonism/antagonism.
  • Pharmaceuticals like 17β-trenbolone are environmental contaminants affecting fish.

Purpose of the Study:

  • To survey recent omics studies on androgenic treatments in fish.
  • To identify common molecular responses to waterborne androgens across diverse fish species and tissues.
  • To construct androgen-responsive protein networks in fish liver.

Main Methods:

  • Transcriptomics and proteomics analyses in fish species (fathead minnow, carp, medaka, zebrafish).
  • Exposure to androgens like 17β-trenbolone, 17α-methyltestosterone, and 17α-methyldihydrotestosterone.
  • Sub-network enrichment analysis of proteomic data from fish liver.

Main Results:

  • Common cellular responses observed across species include apoptosis, lipid metabolism, hormone synthesis, immune response, protein metabolism, and cell proliferation.
  • Alternative mechanisms like toxicant stress and estrogen receptor agonism also contribute to molecular responses.
  • A putative androgen receptor-regulated protein network in fathead minnow liver involves B-lymphocyte differentiation and xenobiotic clearance.

Conclusions:

  • Despite species and tissue diversity, common cellular responses to androgens exist in fish.
  • Androgen receptor activation is not the sole mechanism; other pathways are involved.
  • Protein network construction provides insights into androgen-regulated cellular processes.