Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Amiodarone: a general antiarrhythmic agent].

P Puech1

  • 1Service de cardiologie B, Hôpital Saint-Eloi, Montpellier.

La Revue Du Praticien
|October 21, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MA-QC: Free online software for prostate MR quality control and PI-QUAL assessment.

European journal of radiology·2023
Same author

[Contribution of the pre-operative Mri-coloscan couple in the surgical planning of deep digestive pelvic endometriosis].

Gynecologie, obstetrique, fertilite & senologie·2021
Same author

Predictive Factors of Missed Clinically Significant Prostate Cancers in Men with Negative Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis.

The Journal of urology·2020
Same author

How reproducible are classical and new CT-pelvimetry measurements?

Diagnostic and interventional imaging·2019
Same author

Extra-target low-risk prostate cancer: implications for focal high-intensity focused ultrasound of clinically significant prostate cancer.

World journal of urology·2018
Same author

[Active surveillance in prostate cancer: Assessment of MRI in the selection and follow-up of patients].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2018
Same journal

[Prolonged fever].

La Revue du praticien·2026
Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026
Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026
Same journal

[Patient education in heart failure].

La Revue du praticien·2026
See all related articles

Amiodarone is a potent antiarrhythmic drug that prolongs cardiac repolarization and blocks sodium influx. Its effectiveness in treating cardiac arrhythmias is limited by potential dose-dependent side effects during chronic use.

Area of Science:

  • Pharmacology
  • Cardiology
  • Electrophysiology

Context:

  • Amiodarone, initially developed as an antianginal agent, is widely recognized for its potent antiarrhythmic properties.
  • Its mechanism involves prolonging ventricular repolarization and refractory periods, alongside sodium channel blockade at higher doses.
  • The drug also exhibits non-competitive alpha and beta-adrenergic blocking effects and influences thyroid hormone metabolism.

Purpose:

  • To elucidate the comprehensive pharmacological profile of amiodarone.
  • To detail its electrophysiological effects on cardiac tissues.
  • To understand its interactions with adrenergic receptors and thyroid hormone metabolism.

Summary:

  • Amiodarone uniformly prolongs ventricular repolarization and refractory periods.

Related Experiment Videos

  • At high doses, it inhibits transmembrane sodium influx.
  • Its primary metabolite, desethylamiodarone, possesses significant electrophysiological activity, contributing to the overall antiarrhythmic effect.
  • Non-competitive alpha and beta-adrenolytic effects and interference with thyroid hormone metabolism are key characteristics.
  • Slow accumulation and progressive excretion influence its pharmacokinetic profile.

    • Impact:

    • Amiodarone's broad efficacy in managing cardiac arrhythmias is established.
    • Understanding its complex mechanisms and metabolite activity is crucial for therapeutic application.
    • Potential dose-dependent secondary effects necessitate careful consideration during chronic administration, highlighting the need for ongoing research into its long-term safety and management.