Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma cells with inclusions containing iron.

M Shanmugathasa, H J Sobel, E Marquet

    Archives of Pathology & Laboratory Medicine
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Electron microscopic cytochemistry of 131 I irradiated thyroid gland.

    Archives of pathology·2011
    Same author

    Lipofuscin-iron association in pigmentosis tubae.

    Ultrastructural pathology·1997
    Same author

    Renal disease in Marfan syndrome.

    American journal of nephrology·1996
    Same author

    Heat shock protein 72/73 in normal and diseased kidneys.

    Nephron·1996
    Same author

    Epithelioid leiomyoma of the breast with granular cell change.

    Human pathology·1994
    Same author

    Is malignant mesothelioma being overdiagnosed?

    Ultrastructural pathology·1994

    Iron accumulates in bone marrow plasma cells during folate-deficiency megaloblastic anemia. Electron microscopy suggests iron enters plasma cells via micropinocytosis, potentially from macrophages.

    Area of Science:

    • Hematology
    • Cell Biology
    • Nutritional Science

    Background:

    • Megaloblastic anemia is a condition characterized by large, abnormal red blood cells.
    • Folate deficiency is a common cause of megaloblastic anemia.
    • Iron metabolism plays a crucial role in red blood cell production.

    Observation:

    • Electron microscopy was used to examine iron inclusions within plasma cells in the bone marrow.
    • Plasma cells are immune cells found in the bone marrow.
    • The study focused on an individual diagnosed with megaloblastic anemia due to folate deficiency.

    Findings:

    • Iron inclusions were observed in the plasma cells of the bone marrow.
    • Evidence suggests that iron is internalized by plasma cells through micropinocytosis.

    Related Experiment Videos

  • A potential pathway for iron transfer from reticulum macrophages to plasma cells was proposed.

    • Implications:

    • Understanding iron transport mechanisms in plasma cells can offer insights into anemia pathogenesis.
    • This research may inform future therapeutic strategies for megaloblastic anemia and related iron dysregulation disorders.
    • Further investigation into the macrophage-plasma cell iron transfer pathway is warranted.