Related Experiment Video
Updated: Aug 4, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
Heat shock protein 72/73 in normal and diseased kidneys
1Mt Sinai School of Medicine, New York, N.Y., USA.
Abstract:
The induction of heat shock (stress) proteins (HSP) is a response by cells due to a variety of physical, chemical, and infectious agents. They have a significant role as cytoprotectants, in the regulation of cellular functions, and in the recovery after sublethal injury. Using antibody to mammalian HSP 72/73, we have performed as immunohistological study of human renal tissue in normal and diseased states, including idiopathic nephrotic syndrome, proliferative and crescentic glomerulonephritis, and interstitial nephritis. A significant increase of HSP expression was noted in certain segments of the tubule in acute interstitial nephritis and in glomerulonephritis accompanied by active interstitial inflammation. A possible role by the inflammatory mediators in the induction of HSP in those cases is suggested.
More Related Videos
Related Concept Videos
Kidney Structure
Nephrons
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion
Nephrotic Syndrome II : Assessment and Medical Management
Serum Studies: Renal Function Tests
Acute Kidney Injury II: Pathophysiology

