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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Acute hepatitis E virus infection and autoimmune thyroiditis: yet another trigger?

Franz Ludwig Dumoulin¹, Hanna Liese

¹Department of Medicine, Gemeinschaftskrankenhaus Bonn, Bonn, Germany. f.dumoulin@gk-bonn.de

BMJ Case Reports

|May 19, 2012

Summary

Hepatitis E virus infection may trigger autoimmune thyroiditis in susceptible individuals. This case study highlights a potential link between acute Hepatitis E and the onset of autoimmune thyroiditis, suggesting a novel etiological factor.

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Area of Science:

Hepatology
Endocrinology
Immunology

Background:

Hepatitis E virus (HEV) infection typically causes acute hepatitis.
Autoimmune thyroiditis (AIT) is an organ-specific autoimmune disease.
The co-occurrence of HEV infection and AIT is rarely reported.

Observation:

A middle-aged woman with mild asthma presented with acute hepatitis.
Investigations confirmed acute HEV infection and concurrent autoimmune thyroiditis.
The patient was treated with propranolol and carbimazol.

Findings:

Hepatitis and hyperthyroidism resolved following treatment.
The case suggests HEV infection as a potential trigger for autoimmune thyroiditis.
Pre-existing autoantibodies were considered but deemed less likely.

Implications:

HEV infection might play a role in the pathogenesis of autoimmune thyroiditis.
This association warrants further investigation into HEV's immunomodulatory effects.
Clinicians should consider HEV in patients presenting with hepatitis and thyroid dysfunction.