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Updated: May 22, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Longitudinally extensive transverse myelitis associated with dengue fever
Ashfaq Larik1, Yi Chiong, Lynn Chooi Lee
1Department of Rehabilitation Medicine, Singapore General Hospital, Singapore. ashfaq.ahmed.larik@sgh.com.sg
BMJ Case Reports
|May 19, 2012
Summary
This study reports the first case of longitudinally extensive transverse myelitis (LETM) linked to dengue fever. Early treatment with immunoglobulins, antivirals, and rehabilitation led to excellent patient recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Longitudinally extensive transverse myelitis (LETM) is typically associated with neuromyelitis optica and other autoimmune/inflammatory conditions.
- Dengue fever is known to cause diverse neurological complications, potentially leading to significant disability.
Observation:
- A patient developed LETM during the para-infectious stage of dengue fever.
- The patient experienced severe paraparesis and urinary retention, indicating a complicated clinical course.
Findings:
- This case represents the first documented instance of LETM associated with dengue fever.
- Combined treatment with immunoglobulins, antiviral agents, and intensive rehabilitation yielded excellent recovery outcomes.
Implications:
- Highlights a novel neurological complication of dengue fever, expanding its known spectrum.
- Suggests that prompt and comprehensive treatment can significantly improve recovery from dengue-associated LETM.
- Emphasizes the importance of considering dengue as a potential cause of LETM, especially in endemic regions.
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