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Updated: May 22, 2026
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Th17 cells in immunity to Candida albicans
Nydiaris Hernández-Santos1, Sarah L Gaffen
1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Cell Host & Microbe
|May 22, 2012
Summary
Recent advances in fungal immunity highlight the crucial role of C-type lectin receptors and T helper 17 (Th17) cells in combating Candida albicans infections. These discoveries inform new antifungal therapies and vaccine strategies.
Area of Science:
- Immunology
- Mycology
- Microbiology
Background:
- Immunity to fungal pathogens is an evolving field.
- Discoveries in C-type lectin receptors and Th17 cells have significantly advanced understanding.
- Candida albicans, a common fungus, causes disease in immunocompromised individuals.
Purpose of the Study:
- To discuss recent discoveries in fungal immunity, focusing on Candida albicans.
- To highlight the role of pattern recognition receptors and IL-17 in host defense.
- To explore implications for antifungal biologic therapy and vaccine development.
Main Methods:
- Review of recent fundamental discoveries in fungal immunity.
- Focus on pattern recognition receptor-mediated fungal recognition.
- Analysis of IL-17 responses in host defense against mucosal candidiasis.
Main Results:
- Pattern recognition receptors are vital for detecting fungi.
- IL-17 responses are critical for defense against mucosal candidiasis.
- Advances provide insights into antifungal strategies.
Conclusions:
- Understanding fungal immunity has improved significantly.
- IL-17 plays a key role in host defense against Candida albicans.
- New therapeutic and vaccine approaches are emerging.
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