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[Acquired paraneoplastic hypertrichosis lanuginosa associated with scleroderma].
L Valda Rodriguez1, J Torrico Velasco, R Zeballos Vasconcellos
1Service de dermatologie, Hospital de Clinicas, Universitario, La Paz, Bolivia.
Annales De Dermatologie Et De Venereologie
|January 1, 1990
Summary
Acquired hypertrichosis lanuginosa, a rare cancer symptom, was linked to an undiagnosed lung cancer in a 30-year-old woman. This case highlights unusual associated symptoms and suggests a hormonal basis for paraneoplastic hypertrichosis.
Area of Science:
- Oncology
- Dermatology
- Endocrinology
Background:
- Acquired hypertrichosis lanuginosa is rarely considered a paraneoplastic syndrome.
- This case presents a rare instance of hypertrichosis lanuginosa associated with an internal malignancy.
Observation:
- A 30-year-old woman presented with acquired hypertrichosis lanuginosa and cervical lymph node metastasis.
- Initial investigations failed to locate the primary tumor.
- Autopsy revealed a bronchogenic carcinoma.
Findings:
- The patient exhibited hypertrichosis alongside progressive systemic scleroderma, fissured/hyperpigmented tongue, thrombocytopenia, galactorrhea, alopecia, and nail abnormalities.
- These associated symptoms are not typically described with hypertrichosis lanuginosa.
Implications:
- The constellation of symptoms suggests a potential hormonal etiology for this paraneoplastic hypertrichosis.
- This case broadens the understanding of paraneoplastic syndromes and their diverse clinical presentations.
- Further research into hormonal mechanisms underlying paraneoplastic hypertrichosis is warranted.