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Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
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Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Related Experiment Video

Updated: May 22, 2026

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
10:23

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Published on: January 19, 2017

Functional heterogeneity in the basophil cell lineage.

Mark C Siracusa1, Elia D Tait Wojno, David Artis

  • 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Advances in Immunology
|May 22, 2012
PubMed
Summary

Basophils influence T-helper type 2 (Th2) inflammation, impacting parasitic immunity, asthma, and allergies. Their context-dependent roles in Th2 responses are linked to their diverse functions and activation.

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Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD4(+) T-helper type 2 (Th2) cells mediate immunity to helminths and drive allergic inflammation.
  • Basophils are increasingly recognized for their role in Th2-mediated inflammatory processes.

Purpose of the Study:

  • To review factors regulating basophil development and activation.
  • To describe known basophil effector functions.
  • To discuss basophil heterogeneity and its impact on Th2 inflammation.

Main Methods:

  • Literature review of basophil biology and function.
  • Analysis of studies on basophil heterogeneity in mice and humans.

Main Results:

  • Basophil influence on Th2 inflammation is context-dependent, varying with anatomical location and stimulus.
  • Phenotypic and functional heterogeneity exists within basophil populations.
  • These heterogeneities may explain the varied roles of basophils in Th2 inflammation.

Conclusions:

  • Basophils play multifaceted roles in Th2 cytokine-associated inflammation, acting in propagation, regulation, or effector phases.
  • Understanding basophil heterogeneity is crucial for deciphering their precise contributions to allergic diseases and parasitic infections.