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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Impact of excipient interactions on drug bioavailability from solid dosage forms
Ravikiran Panakanti1, Ajit S Narang
1Department of Biopharmaceutical Sciences, Roosevelt University, 1400 N Roosevelt Blvd., SCH 250, Schaumburg, Illinois, 60173, USA. rpanakanti@roosevelt.edu
Pharmaceutical Research
|May 22, 2012
Summary
Understanding drug-excipient interactions is key to improving drug bioavailability. This study explores how excipients in solid dosage forms affect drug absorption and product properties.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Pharmacokinetics
Background:
- Excipients are typically inert but can influence drug bioavailability through interactions.
- Understanding these interactions is crucial for developing effective drug products.
- Solid dosage forms present unique challenges for drug absorption.
Purpose of the Study:
- To investigate drug-excipient interactions in solid dosage forms.
- To elucidate the impact of excipients on drug bioavailability.
- To explore how excipients affect drug substance and product properties.
Main Methods:
- Review of existing literature on drug-excipient interactions.
- Analysis of factors influencing drug absorption (e.g., solubility, permeability).
- Examination of excipient effects on physiological processes at the absorption site.
Main Results:
- Drug-excipient interactions can significantly alter drug bioavailability.
- Excipients impact drug release, absorption kinetics, and stability.
- Factors like drug potency, dose, and absorption site influence interaction effects.
Conclusions:
- A mechanistic understanding of drug-excipient interactions is essential for formulation design.
- Optimizing formulations based on these interactions can enhance drug bioavailability.
- This knowledge aids in developing robust and effective drug products.
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