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Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
Carbohydrate to carbohydrate interaction in development process and cancer progression
Kazuko Handa1, Sen-Itiroh Hakomori
1Pacific Northwest Research Institude, WA 98122, USA. hakomori@u.washington.edu
Glycoconjugate Journal
|May 22, 2012
Summary
Carbohydrate-to-carbohydrate interactions (CCI) mediate cell adhesion and signaling. Research reveals two types, trans-CCI and cis-CCI, impacting embryonic development and cancer metastasis.
Area of Science:
- Glycobiology
- Cell Biology
- Developmental Biology
Background:
- Carbohydrate-to-carbohydrate interactions (CCI) are crucial in biological processes.
- Two main types, trans-CCI (intercellular) and cis-CCI (intracellular), are recognized.
Purpose of the Study:
- To review known examples of CCI in biological contexts.
- To highlight the roles of CCI in embryonic development and cancer progression.
Main Methods:
- Literature review of studies on carbohydrate-to-carbohydrate interactions.
- Analysis of molecular mechanisms underlying CCI in cell adhesion, signaling, and receptor activation.
Main Results:
- Trans-CCI examples include Le(x)-Le(x) interactions in mouse embryo compaction and GM3 interactions in tumor metastasis.
- Cis-CCI examples involve GM3 inhibiting epidermal growth factor receptor (EGFR) activation and GM3/GM2 complexes inhibiting hepatocyte growth factor (HGF) receptor (cMet) activation.
Conclusions:
- CCI plays significant roles in both embryonic development and cancer progression.
- Further research is needed to uncover additional CCI functions in biological systems.
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