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Diffusion tensor imaging in hydrocephalus--findings before and after shunt surgery
Michael Scheel1, Torsten Diekhoff, Christian Sprung
1Department of Neuroradiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. michael.scheel@charite.de
Acta Neurochirurgica
|May 22, 2012
Summary
Diffusion tensor imaging (DTI) reveals regional changes in hydrocephalus (HC) patients. Shunt surgery shows a trend toward normalizing DTI parameters, but differences persist compared to controls.
Area of Science:
- Neuroimaging
- Medical Physics
- Neurology
Background:
- Hydrocephalus (HC) presents complex challenges in neurological assessment.
- Diffusion Tensor Imaging (DTI) offers insights into white matter integrity.
Purpose of the Study:
- To evaluate changes in DTI-derived parameters in hydrocephalus patients.
- To assess the impact of shunt surgery on these DTI parameters.
Main Methods:
- Thirteen hydrocephalus patients underwent DTI scans pre- and post-shunt surgery.
- Combined region of interest and voxel-based analysis compared patient data with age-matched controls.
Main Results:
- DTI parameter alterations in hydrocephalus were region-specific.
- Increased fractional anisotropy was observed in the corticospinal tract; decreased in the corpus callosum.
- Shunt surgery initiated a trend toward normalization of DTI parameters, though differences from controls remained.
Conclusions:
- DTI parameter changes in hydrocephalus are regionally dependent.
- Careful interpretation of underlying diffusivities is crucial for diagnostic and follow-up utility.
- DTI may serve as a valuable tool for monitoring hydrocephalus progression and treatment response.
