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Updated: May 22, 2026

In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
Published on: March 21, 2017
Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update
James Samuel McLaren1, Edward Morris, Janice Rymer
1Department of Obstetrics and Gynaecology, Guy’s and St Thomas’ Hospital, London, UK. jsmclaren@doctors.org.uk
Abstract:
Gonadotrophin receptor hormone analogues (GnRHa) have been used in a range of sex hormone-dependent disorders. In the management of premenstrual syndrome, they can completely abolish symptoms. The success of GnRHa in the treatment of endometriosis and adjuvant therapy in the management of fibroids is proven. This efficacy does not come without a cost and the side-effects of the hypo-estrogenic state have limited their application. The use of add-back therapy to counter these effects has enabled wider application, longer durations of treatment and an increase in compliance. This review article is an update on the evidence supporting gonadotrophin receptor hormone analogues in combination with add-back therapy.
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