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Potential strategies to avoid progestogen-induced premenstrual disorders.

Lucy J Baker¹, P M S O'Brien

¹Obstetrics & Gynaecology, Keele University, School of Medicine, Newcastle Road, Stoke-On-Trent ST4 6QG, UK.

Menopause International

|May 22, 2012

Summary

Many hormonal treatments for premenstrual syndrome (PMS) can cause PMS-like symptoms due to progestogen. Progestogen-induced premenstrual disorder is often overlooked, requiring clinical experience for management.

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Area of Science:

Gynecology
Endocrinology
Women's Health

Background:

Non-hormonal treatments for premenstrual syndrome (PMS), like SSRIs, are not universally effective.
Hormonal therapies are frequently necessary but can paradoxically induce or worsen PMS-like symptoms.

Purpose of the Study:

To highlight the underrecognized link between progestogen use and PMS-like symptoms.
To introduce the concept of progestogen-induced premenstrual disorder.
To emphasize the reliance on clinical experience due to a lack of robust research.

Main Methods:

Review of clinical observations and theoretical strategies in managing premenstrual disorders.
Analysis of hormonal therapies commonly used in gynecology and their potential side effects.
Identification of situations where progestogen is used and may contribute to symptoms.

Main Results:

Progestogen, a component of many hormonal treatments, can cause or exacerbate PMS symptoms.
This phenomenon, termed progestogen-induced premenstrual disorder, is often missed by healthcare professionals.
Managing these symptoms is challenging due to the need for endometrial protection.

Conclusions:

The link between progestogen and PMS-like symptoms is a significant clinical issue.
Progestogen-induced premenstrual disorder requires greater recognition and clinical attention.
Empirical findings and clinical experience are currently crucial for managing these conditions in the absence of extensive research.