Potential strategies to avoid progestogen-induced premenstrual disorders

Area of Science:

• Gynecology
• Endocrinology
• Women's Health

Background:

• Non-hormonal treatments for premenstrual syndrome (PMS), like SSRIs, are not universally effective.
• Hormonal therapies are frequently necessary but can paradoxically induce or worsen PMS-like symptoms.

Purpose of the Study:

• To highlight the underrecognized link between progestogen use and PMS-like symptoms.
• To introduce the concept of progestogen-induced premenstrual disorder.
• To emphasize the reliance on clinical experience due to a lack of robust research.

Main Methods:

• Review of clinical observations and theoretical strategies in managing premenstrual disorders.
• Analysis of hormonal therapies commonly used in gynecology and their potential side effects.
• Identification of situations where progestogen is used and may contribute to symptoms.

Main Results:

• Progestogen, a component of many hormonal treatments, can cause or exacerbate PMS symptoms.
• This phenomenon, termed progestogen-induced premenstrual disorder, is often missed by healthcare professionals.
• Managing these symptoms is challenging due to the need for endometrial protection.

Conclusions:

• The link between progestogen and PMS-like symptoms is a significant clinical issue.
• Progestogen-induced premenstrual disorder requires greater recognition and clinical attention.
• Empirical findings and clinical experience are currently crucial for managing these conditions in the absence of extensive research.