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Chronic Obstructive Pulmonary Disease

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Related Experiment Video

Updated: May 22, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

D-dimer levels in stable COPD patients: a case-control study.

Denise Rossato Silva¹, Ana Cláudia Coelho, Marcelo Basso Gazzana

¹Universidade Federal do Rio Grande do Sul, Brazil. denise.rossato@terra.com.br

|May 23, 2012

Summary

This summary is machine-generated.

D-dimer levels did not differ between stable chronic obstructive pulmonary disease (COPD) patients and controls. Body mass index (BMI) showed a correlation with D-dimer levels in COPD patients, suggesting potential coagulation disturbances.

Related Experiment Videos

Last Updated: May 22, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

Pulmonary Medicine
Hematology
Clinical Diagnostics

Background:

Elevated D-dimer levels are observed in chronic obstructive pulmonary disease (COPD) exacerbations, regardless of venous thromboembolism.
The diagnostic utility of D-dimer testing in stable COPD remains debated.

Purpose of the Study:

To determine if stable COPD patients exhibit a hypercoagulable state via basic laboratory investigations.
To examine the association between D-dimer levels, pulmonary function tests, and body mass index (BMI) in stable COPD.

Main Methods:

A case-control study design was employed, matching COPD patients with control subjects in a 2:1 ratio for age and sex.
D-dimer levels and pulmonary function tests were measured in both COPD patients and control groups.
Bivariate correlation analysis was used to assess relationships between variables.

Main Results:

No statistically significant difference in median D-dimer levels was found between 58 COPD patients (0.24 ng/mL) and 30 controls (0.17 ng/mL).
A significant positive correlation was identified between BMI and D-dimer levels in the COPD cohort (r = 0.3, p = 0.024).

Conclusions:

D-dimer levels in stable COPD patients are comparable to those in healthy controls.
Elevated BMI may contribute to coagulation system disturbances in patients with stable COPD.