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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: May 22, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Recent development in software and automation tools for high-throughput discovery bioanalysis.

Wilson Z Shou1, Jun Zhang

  • 1Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA. wilson.shou@bms.com

Bioanalysis
|May 23, 2012
PubMed
Summary
This summary is machine-generated.

High-throughput (HT) bioanalysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in drug discovery demands automation. Software and automation tools streamline sample preparation, analysis, and data review, improving efficiency and reducing turnaround time.

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Cost-Efficient Transcriptomic-Based Drug Screening
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Last Updated: May 22, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Biotechnology

Background:

  • Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the standard for quantitative drug analysis in biological samples.
  • Early drug discovery requires high-throughput (HT) analysis of numerous diverse compounds with rapid turnaround times.
  • Discovery bioanalysis quality standards are typically less stringent than those for drug development.

Purpose of the Study:

  • To review recent advancements in automation for high-throughput (HT) bioanalysis in drug discovery.
  • To discuss software tools that support individual bioanalytical procedures and integrated workflows.
  • To cover software for emerging high-resolution accurate mass (HRAM) bioanalytical methods.

Main Methods:

  • Review of automation technologies for sample preparation.
  • Examination of software for automated LC-MS/MS method development and analysis.
  • Discussion of integrated software solutions for managing HT bioanalytical workflows.
  • Inclusion of software tools for high-resolution accurate mass (HRAM) spectrometry.

Main Results:

  • Automation significantly enhances efficiency and reduces turnaround time in HT bioanalysis.
  • Software tools effectively streamline individual steps and entire workflows.
  • Emerging HRAM approaches are being supported by dedicated software solutions.
  • Automation maintains adequate quality standards for discovery bioanalysis.

Conclusions:

  • Automation is crucial for efficient HT bioanalysis in drug discovery.
  • Integrated software platforms optimize the entire bioanalytical workflow.
  • Software advancements support both traditional and novel bioanalytical techniques like HRAM-MS.