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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Published on: November 16, 2018

Analysis of bone formation after sinus augmentation using β-tricalcium phosphate.

Ulrike Schulze-Späte1, Thomas Dietrich, Rayyan A Kayal

  • 1Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, New York, USA.

Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995)
|May 24, 2012
PubMed
Summary

Beta-tricalcium phosphate effectively augments maxillary sinus bone for dental implants. This bone graft material showed good bone development and no inflammatory reactions, leading to successful implant integration.

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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Area of Science:

  • Oral and Maxillofacial Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Maxillary sinus augmentation is crucial for dental implant placement in cases of bone height deficiency.
  • Beta-tricalcium phosphate (β-TCP) is a synthetic bone graft material with osteoconductive properties.
  • Evaluating β-TCP's efficacy in maxillary sinus augmentation is essential for predictable clinical outcomes.

Purpose of the Study:

  • To assess the bone development and maturation process in the maxillary sinus after augmentation with beta-tricalcium phosphate.
  • To evaluate the biocompatibility and osteogenic potential of beta-tricalcium phosphate in human subjects.
  • To determine the long-term success of dental implants placed in conjunction with beta-tricalcium phosphate sinus augmentation.

Main Methods:

  • A case series involving maxillary sinus augmentation using beta-tricalcium phosphate.
  • Bone biopsies were collected between 21 and 40 weeks post-augmentation for histological analysis.
  • Staining techniques including Hematoxylin and Eosin (H&E), Goldner's, and tartrate-resistant acid phosphatase (TRAP) were employed.
  • Dental implants were placed simultaneously with bone biopsy and followed for 12 months.

Main Results:

  • Histological analysis revealed an increase in total bone volume over time with a corresponding decrease in beta-tricalcium phosphate particles.
  • No significant inflammatory reactions were observed around the graft material.
  • TRAP staining indicated the presence of osteoclasts actively resorbing the remaining graft particles.
  • All placed implants demonstrated successful osseointegration and stability over the 12-month follow-up period.

Conclusions:

  • Beta-tricalcium phosphate serves as an effective bone graft material for maxillary sinus augmentation, promoting bone formation and integration.
  • The material exhibits excellent biocompatibility, with minimal inflammatory response and evidence of osteoclast-mediated remodeling.
  • Successful dental implant outcomes can be achieved following sinus augmentation with beta-tricalcium phosphate, highlighting its clinical utility.