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Salmonella enteritidis causing joint sepsis.

V Kyle1, M Chard, S Ramsey

  • 1Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK.

Clinical Rheumatology
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

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Salmonella Enteritidis is rarely found in joints, but can infect immunosuppressed individuals. This case highlights a rare joint infection by Salmonella Enteritidis in a patient with medulloblastoma.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Oncology

Background:

  • Medulloblastoma is a common pediatric brain tumor.
  • Dexamethasone is a corticosteroid used to reduce inflammation and swelling.
  • Salmonella Enteritidis is a common cause of foodborne illness.

Observation:

  • A 22-year-old male, post-medulloblastoma resection and on dexamethasone, presented with acute knee pain and swelling.
  • Synovial fluid analysis revealed active metalloproteinases without inhibitors, indicative of septic arthritis.
  • Salmonella Enteritidis was cultured from the knee joint fluid and one stool sample.

Findings:

  • This case represents an extremely rare instance of Salmonella Enteritidis causing septic arthritis.
  • The patient had no gastrointestinal symptoms, suggesting non-traditional routes of infection.

Related Experiment Videos

  • Active metalloproteinases in synovial fluid are characteristic of septic joints.

    • Implications:

    • The findings suggest that immunosuppression, such as that induced by dexamethasone therapy, may facilitate Salmonella Enteritidis joint infections.
    • Recent identification of Salmonella Enteritidis in poultry and eggs indicates potential foodborne sources.
    • This case underscores the importance of considering Salmonella Enteritidis in septic arthritis, even without typical gastrointestinal symptoms, in immunocompromised patients.