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Nano-titanium dioxide modulates the dermal sensitization potency of DNCB
Salik Hussain1, Stijn Smulders, Vanessa De Vooght
1Unit of Functional and Adaptive Biology CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Univ Paris Diderot, Sorbonne Paris Cité, France.
Particle and Fibre Toxicology
|May 25, 2012
Summary
Titanium dioxide nanoparticles (TiO(2) NPs) enhanced the dermal sensitization potency of dinitrochlorobenzene (DNCB). This immunomodulatory effect was linked to an augmented Th(2) response, increasing IL-4 and decreasing IL-10 production.
Area of Science:
- Nanotechnology
- Immunology
- Dermatology
Background:
- Nanoparticles (NPs) have shown immunomodulatory potential.
- Titanium dioxide (TiO(2)) is a model NP used in various applications.
- Dinitrochlorobenzene (DNCB) is a known potent dermal sensitizer.
Purpose of the Study:
- To determine if TiO(2) NPs can modulate dermal sensitization induced by DNCB.
- To investigate the underlying immunological mechanisms of NP-induced sensitization modulation.
Main Methods:
- Local lymph node proliferation assay in BALB/c mice.
- Assessment of DNCB EC(3)-value in the presence and absence of TiO(2) NPs.
- Analysis of lymphocyte subpopulations and cytokine profiles (IL-4, IL-10).
Main Results:
- TiO(2) NPs significantly increased DNCB-induced lymph node proliferation.
- The EC(3) value for DNCB was reduced in the presence of TiO(2) NPs.
- TiO(2) NPs augmented Th(2) responses by increasing IL-4 and decreasing IL-10 levels.
Conclusions:
- Nano-TiO(2) enhances the dermal sensitization potency of DNCB.
- This enhancement is mediated by augmenting Th(2) immune responses.
- NPs possess immunomodulatory abilities that can affect dermal sensitization.
