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Adipokine levels are altered by shiftwork: a preliminary study.

Cibele Aparecida Crispim1, Heloisa Guarita Padilha, Ioná Zalcman Zimberg

  • 1Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Chronobiology International
|May 25, 2012
PubMed
Summary
This summary is machine-generated.

Shiftwork alters key cytokine levels, impacting insulin resistance and cardiovascular disease risk. Early morning and night shifts showed lower adiponectin and higher tumor necrosis factor-alpha (TNF-α) compared to day shifts.

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Published on: August 8, 2019

Area of Science:

  • Metabolic health
  • Chronobiology
  • Immunology

Background:

  • Shiftwork is linked to metabolic diseases and insulin resistance.
  • Cytokines like adiponectin, TNF-α, and IL-6 are implicated in these conditions.

Purpose of the Study:

  • To compare concentrations of adiponectin, TNF-α, and IL-6 in young adult men on night, early morning, and day shifts.
  • To investigate the impact of shiftwork on cytokine profiles related to metabolic health.

Main Methods:

  • Blood samples collected over 24 hours from three groups: fixed night shift, early morning shift, and day shift.
  • Analysis of adiponectin, TNF-α, and IL-6 levels.
  • Comparison of dietary intake (fat, carbohydrate, total energy) and physical activity.

Main Results:

  • Shift workers consumed higher fat and lower carbohydrate diets.
  • Early morning shift workers had lower mean adiponectin levels.
  • Both early morning and night shift workers showed higher mean TNF-α levels compared to day workers.
  • No significant differences in IL-6 levels or circadian effects were observed for any cytokine.

Conclusions:

  • Shiftwork, particularly early morning and night shifts, is associated with altered cytokine secretion (adiponectin, TNF-α).
  • These alterations may contribute to increased susceptibility to insulin resistance and cardiovascular disease in shift workers.