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Updated: May 22, 2026

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Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents

Esther Schuh1, Carolin Pflüger, Anna Citta

  • 1Fachbereich C, Anorganische Chemie, Bergische Universität Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.

Journal of Medicinal Chemistry
|May 25, 2012
PubMed
Summary

New gold(I) complexes with N-heterocyclic carbene ligands exhibit potent antiproliferative effects against ovarian cancer cells. These compounds selectively inhibit thioredoxin reductase (TrxR), leading to significant cell death.

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