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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Alerting network dysfunction in early multiple sclerosis.

Lucía Crivelli1, Mauricio F Farez, Claudio D González

  • 1Department of Neurology, Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

Journal of the International Neuropsychological Society : JINS
|May 25, 2012
PubMed
Summary
This summary is machine-generated.

Early multiple sclerosis (MS) patients show impaired alerting attention. While orienting and executive control networks remain unaffected, MS specifically impacts the alerting network

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Clinical Neurology

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) is a central nervous system autoimmune disease.
  • Cognitive deficits, particularly in attention, are common in MS patients.
  • Early detection of attention deficits is crucial for managing RRMS.

Purpose of the Study:

  • To assess attention networks in recently diagnosed RRMS patients with low disability.
  • To compare the efficiency of three attentional networks (Alerting, Orienting, Executive Control) between early RRMS patients and healthy controls.
  • To identify specific attentional domains affected in early RRMS.

Main Methods:

  • Utilized the Attentional Network Test (ANT), a computerized assessment.
  • Included 27 early RRMS patients (EDSS<2) and 27 matched healthy controls.
  • Measured efficiency in the Alerting, Orienting, and Executive Control attentional networks.

Main Results:

  • RRMS patients demonstrated significantly reduced efficiency in the Alerting network (p = .006).
  • No significant differences were found between RRMS patients and controls in the Orienting and Executive Control networks.
  • A significant interaction between Alerting and Executive Control networks was observed in RRMS patients (p = .007).

Conclusions:

  • Early relapsing-remitting multiple sclerosis primarily affects the Alerting domain of attention.
  • The Orienting and Executive Control domains of attention appear preserved in early RRMS.
  • Findings suggest a specific vulnerability of the Alerting network in early MS, with potential interplay with Executive Control.