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A Chromatin Assay for Human Brain Tissue
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Epigenetics of major psychosis: progress, problems and perspectives
Viviane Labrie1, Shraddha Pai, Arturas Petronis
1The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ONT, M5T 1R8, Canada.
Trends in Genetics : TIG
|May 25, 2012
Summary
Epigenetic modifications, beyond DNA and environment, may influence behavior and psychiatric disorders like schizophrenia and bipolar disorder. Research explores these epigenetic factors in brain tissue for disease origins.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Understanding behavior origins is key in biomedical research.
- Epigenetic modifications are increasingly recognized as contributors to complex phenotypes.
- Epigenetics offers a promising avenue for studying psychiatric disease etiology.
Purpose of the Study:
- To review recent epigenetic studies in psychiatric disorders.
- To examine epigenetic factors in brain and other tissues.
- To discuss the role of epigenetics in schizophrenia and bipolar disorder.
Main Methods:
- Review of current epigenetic research.
- Analysis of studies on brain and tissue samples.
- Examination of epigenetic modifications in DNA and histone proteins.
Main Results:
- Epigenetic factors play a role in normal and pathological behavior.
- Evidence links epigenetic modifications to complex phenotypes.
- Studies include individuals with schizophrenia and bipolar disorder.
Conclusions:
- Epigenetics is a crucial area for understanding psychiatric disease origins.
- Further research into psychiatric epigenetics is warranted.
- Future directions in psychiatric epigenetics are highlighted.
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