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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Related Experiment Video

Updated: May 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Update on systemic therapies for atopic dermatitis.

Kristopher S Denby1, Lisa A Beck

  • 1Department of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA.

Current Opinion in Allergy and Clinical Immunology
|May 25, 2012
PubMed
Summary

Systemic therapies for atopic dermatitis (eczema) are reviewed, highlighting updated risks and benefits. Azathioprine use requires caution; NBUVB, mycophenolate, and methotrexate are preferred first-line options.

Related Experiment Videos

Last Updated: May 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Atopic dermatitis (eczema) often requires systemic therapies for severe cases.
  • Clinicians and patients need current data on systemic treatment risks and benefits.

Purpose of the Study:

  • To review the latest literature on systemic therapies for atopic dermatitis.
  • To guide selection of appropriate therapies based on patient-specific factors.

Main Methods:

  • Review of recent randomized controlled trials (RCTs) of systemic atopic dermatitis treatments.
  • Analysis of emerging data on risk-benefit profiles of established and novel therapies.

Main Results:

  • Updated risk-benefit data alter the landscape of systemic atopic dermatitis treatments.
  • Head-to-head RCTs provide new comparative information.
  • Targeted therapies offer insights into disease pathogenesis.

Conclusions:

  • Caution is advised with azathioprine due to lymphoma risk.
  • NBUVB, mycophenolate, and methotrexate are recommended first-line systemic options.
  • Novel targeted therapies and understanding immunopathogenesis are future directions.