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The blink reflex in cluster headache.

F Raudino1

  • 1Neurological Department, Valduce Hospital, Como, Italy.

Headache
|September 1, 1990
PubMed
Summary

Cluster headache may involve the trigeminal system, as evidenced by a reduced blink reflex on the affected side. This finding suggests the blink reflex can monitor cluster headache activity and treatment effects.

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Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Cluster headache is a debilitating neurological disorder characterized by severe unilateral head pain.
  • The trigeminal system is implicated in the pathophysiology of cluster headache.

Purpose of the Study:

  • To investigate the role of the trigeminal system in cluster headache.
  • To evaluate the utility of the blink reflex as a biomarker in cluster headache.

Main Methods:

  • Electrically-elicited blink reflex was measured in twelve subjects during a symptomatic period of cluster headache.
  • The amplitude of the contralateral R2 response was compared between the symptomatic and asymptomatic sides.

Main Results:

  • A significantly lower amplitude of the contralateral R2 blink reflex response was observed on the symptomatic side in eleven out of twelve subjects (p = 0.005).
  • This reduction occurred at the same stimulus intensity, indicating a specific neurophysiological change.

Conclusions:

  • The trigeminal system appears to be involved in the pathophysiology of cluster headache.
  • The blink reflex serves as a sensitive indicator for assessing biological phenomena and drug-induced changes in cluster headache.

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