Primary malignant melanoma of proximal tibia
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Updated: May 22, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Aditya K Mootha1, Kamal Bali, Vishal Kumar
1Department of Orthopedics, PGIMER, Chandigarh, India.
Abstract:
Primary malignant melanoma (clear cell sarcoma) of bone is a very rare neoplasm. Although metastatic melanoma to bone is not uncommon, primary malignant melanoma of bone is extremely uncommon. To date, only nine cases have been reported in the English literature. In this report, we present a case of primary malignant melanoma arising from the medial aspect of the proximal tibia in a 26-year-old woman. We treated the patient with above-knee amputation without any chemotherapy or radiotherapy. At final follow-up of 18 months, the patient was free of disease.
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