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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Australian Rotavirus Surveillance Program annual report, 2010/11
Carl D Kirkwood1, Susie Roczo, Karen Boniface
1Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria. carl.kirkwood@mcri.edu.au
Communicable Diseases Intelligence Quarterly Report
|May 26, 2012
Summary
Rotavirus genotype G2P[4] became the dominant strain in Australia during 2010-2011, following vaccine introduction. Annual changes in dominant rotavirus strains highlight a dynamic wild-type population.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- The Australian Rotavirus Surveillance Program monitors rotavirus strains nationwide.
- This report covers the fourth year of surveillance after rotavirus vaccines were introduced into the National Immunisation Program.
Purpose of the Study:
- To determine the G and P genotypes of rotavirus strains causing acute gastroenteritis hospitalizations in Australia from July 1, 2010, to June 30, 2011.
- To analyze changes in dominant rotavirus genotypes in the post-vaccine era.
Main Methods:
- Laboratory-based surveillance of rotavirus strains.
- G and P genotype analysis of 1,127 fecal samples using hemi-nested multiplex reverse transcription-polymerase chain reaction (RT-PCR).
- Confirmation of 816 rotavirus-positive samples.
Main Results:
- Genotype G2P[4] emerged as the dominant strain, accounting for 51% of cases.
- Other prevalent genotypes included G1P[8] (26.1%), G3P[8] (11%), and G4P[8] (6%).
- Uncommon combinations like G2P[8] and G9P[4] were identified, and genotype distribution varied by state, potentially linked to vaccine usage.
Conclusions:
- A shift in dominant rotavirus genotypes was observed, with G2P[4] becoming predominant.
- Annual fluctuations in dominant genotypes suggest a dynamic wild-type rotavirus population.
- Ongoing surveillance is crucial for understanding rotavirus epidemiology in the context of vaccination programs.
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