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Related Experiment Video

Updated: May 22, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Polyhexamethylene biguanide functionalized cationic silver nanoparticles for enhanced antimicrobial activity.

Sumaira Ashraf¹, Nasrin Akhtar, Muhammad Afzal Ghauri

¹Department of Chemistry, School of Science & Engineering (SSE), Lahore University of Management Sciences (LUMS), DHA, Lahore Cantt, 54792, Pakistan. ihussain@lums.edu.pk.

Nanoscale Research Letters

|May 26, 2012

Summary

Polyhexamethylene biguanide (PHMB) stabilized silver nanoparticles show enhanced antimicrobial activity against E. coli. These nanoparticles are highly effective for textile applications due to PHMB

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Area of Science:

Materials Science
Nanotechnology
Microbiology

Background:

Polyhexamethylene biguanide (PHMB) is a broad-spectrum disinfectant.
Silver nanoparticles (AgNPs) possess antimicrobial properties.
Developing effective antimicrobial agents for various applications is crucial.

Purpose of the Study:

To synthesize PHMB-functionalized silver nanoparticles.
To characterize the synthesized nanoparticles.
To evaluate the antimicrobial efficacy of PHMB-AgNPs against Escherichia coli.

Main Methods:

Synthesis of silver nanoparticles using PHMB as a stabilizing ligand.
Characterization via UV-visible spectroscopy, FTIR, DLS, electrophoretic mobility, and TEM.
Antimicrobial activity testing against Gram-negative E. coli.

Main Results:

Uniform silver nanoparticles functionalized with PHMB were successfully synthesized.
Characterization confirmed particle morphology and surface chemistry.
PHMB-AgNPs exhibited approximately 100-fold higher bacteriostatic and bactericidal activity compared to previous reports.
Enhanced activity is attributed to the synergistic effect of silver nanoparticles and PHMB.

Conclusions:

PHMB-functionalized silver nanoparticles demonstrate potent antimicrobial properties.
The strong interaction of PHMB with cellulose makes these nanoparticles highly suitable for the textile industry.
This study presents a promising approach for developing advanced antimicrobial materials.