Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haplotype analysis of spinocerebellar ataxia type 36 suggests a shared permissive core haplotype across populations.

Journal of human genetics·2026
Same author

Two scripts, two pathways: dorsal-ventral biases in post-stroke kana-kanji agraphia.

Brain : a journal of neurology·2026
Same author

Leptomeningeal Carcinomatosis Arising 29 Years After Gastrectomy: A Report of a Rare Autopsy Case.

Cureus·2026
Same author

Real-world outcomes and early discontinuation of foslevodopa/foscarbidopa in Parkinson's disease.

Journal of neurology·2026
Same author

Asthma-like bronchodilator responsiveness in patients with neuronal intranuclear inclusion disease.

Scientific reports·2026
Same author

Complete remission of intracranial lymphocytic vasculitis following resection: illustrative case.

Journal of neurosurgery. Case lessons·2026

Related Experiment Video

Updated: May 22, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis.

Joe Senda1, Hirohisa Watanabe, Takashi Tsuboi

  • 1Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

Journal of the Neurological Sciences
|May 26, 2012
PubMed
Summary

Magnetic resonance imaging (MRI) reveals widespread brain abnormalities in multiple sclerosis (MS) patients. Diffusion tensor imaging (DTI), particularly mean diffusivity (MD), showed more extensive degeneration than other MRI metrics, correlating with disease severity and duration.

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: May 22, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • Accurate assessment of brain changes in MS is crucial for understanding disease progression and disability.
  • Advanced magnetic resonance imaging (MRI) techniques offer detailed insights into brain pathology.

Purpose of the Study:

  • To investigate brain abnormalities in multiple sclerosis (MS) patients using a combination of MRI techniques.
  • To compare the sensitivity of different MRI metrics in detecting widespread brain degeneration.
  • To correlate imaging findings with clinical measures of disease severity and duration.

Main Methods:

  • Voxel-based morphometry (VBM) for gray matter volume analysis.
  • Voxel-based analysis of fluid-attenuated inversion recovery (FLAIR) high-intensity lesions.
  • Diffusion tensor imaging (DTI) to assess white matter integrity, including fractional anisotropy and mean diffusivity (MD).
  • Comparison between 32 MS patients and 18 healthy controls.

Main Results:

  • MS patients exhibited gray matter volume reduction in key brain regions (thalamus, hypothalamus, caudate, limbic lobe, frontal lobe).
  • Significant white matter volume reduction was observed along the lateral ventricles and corpus callosum.
  • Diffusion tensor imaging (DTI) revealed reduced fractional anisotropy mirroring FLAIR lesions, with increased mean diffusivity (MD) being the most widespread abnormality, extending into normal-appearing white matter.
  • Increased MD values showed significant correlations with longer disease duration and higher Expanded Disability Status Scale (EDSS) scores.

Conclusions:

  • Combined voxel-based MRI analysis (volumetry, FLAIR, DTI) effectively detects widespread brain abnormalities in MS.
  • Diffusion tensor imaging (DTI), especially mean diffusivity (MD), is a highly sensitive marker for widespread neurodegeneration in MS.
  • DTI findings, particularly MD, correlate significantly with clinical disease severity and duration, highlighting its prognostic value.