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Related Experiment Videos

Attempted murder with pancuronium.

E J Briglia1, P L Davis, M Katz

  • 1Division of Medical-Legal Investigations and Forensic Sciences, County of Suffolk, Hauppauge, NY.

Journal of Forensic Sciences
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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A nurse used pancuronium, a neuromuscular blocking agent, to poison her husband. Advanced analytical methods, including gas chromatography/mass spectrometry (GC/MS), confirmed the presence of pancuronium in urine samples, leading to legal adjudication.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • A case involving alleged poisoning by a nurse using a neuromuscular blocking agent.
  • The need for reliable methods to detect specific drugs in biological samples.

Observation:

  • Urine samples were collected from the victim following two suspected poisoning incidents.
  • Initial screening using fluorometry with Rose Bengal dye indicated presumptive positive results for pancuronium.

Findings:

  • Confirmation of pancuronium was achieved through a multi-step process.
  • This involved complexation with potassium iodide, thin-layer chromatography (TLC) cleanup, and gas chromatography/mass spectrometry (GC/MS) analysis.
  • GC/MS analysis, utilizing selected-ion monitoring, detected characteristic fragments of pancuronium after pyrolytic N-demethylation.

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Implications:

  • The validated analytical method provided crucial evidence for the legal case.
  • Highlights the importance of advanced forensic toxicology in criminal investigations.
  • Demonstrates the utility of GC/MS in identifying complex quaternary amines in biological matrices.