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Tailoring layer-by-layer capsules for biomedical applications.

Marie-Luce De Temmerman1, Jo Demeester, Stefaan C De Smedt

  • 1Laboratory of General Biochemistry & Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

Nanomedicine (London, England)
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

Layer-by-layer polymeric capsules offer versatile drug delivery. This review explores their biomedical applications, focusing on stimuli-responsive systems for targeted payload release and future therapeutic potential.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Polymeric capsules are recognized as adaptable carriers in medicine and pharmaceutics.
  • These capsules are fabricated using layer-by-layer adsorption onto a template core, enabling the creation of hollow structures.
  • The capsule's internal cavity can encapsulate diverse cargo molecules, and its walls can be modified for specific functionalities.

Purpose of the Study:

  • To review the generation of tailored layer-by-layer capsules.
  • To highlight the potential biomedical applications of this multifunctional delivery platform.
  • To discuss the current status, opportunities, and challenges for therapeutic and diagnostic applications.

Main Methods:

  • Stepwise layer-by-layer adsorption of polymers onto a template core.
  • Functionalization of capsule walls by embedding specific moieties into multilayers.
  • Removal of the template core to yield hollow capsules.

Main Results:

  • Tuning capsule properties influences interactions with cells and tissues.
  • Development of stimuli-responsive capsules for targeted payload release is feasible.
  • The technology shows promise for multifunctional delivery systems.

Conclusions:

  • Layer-by-layer polymeric capsules represent a promising platform for advanced drug delivery.
  • Further research is needed to overcome hurdles for successful clinical translation in diagnostics and therapeutics.
  • Tailored capsule design enables precise control over drug release and targeting.