Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

Diabetes: Management and Pharmacotherapy

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Teriparatide-induced Sever Persistent Hypercalcemia in an Osteoporotic Patient: A Case Report and Literature Review.

The archives of bone and joint surgery·2025

Same author

Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study.

Scientific reports·2025

Same author

Is There a Relation between Hypothyroidism and Polycystic Ovary Syndrome and its Metabolic Components?

Current diabetes reviews·2022

Same author

Effect of crocin on diabetic patients: A placebo-controlled, triple-blinded clinical trial.

Clinical nutrition ESPEN·2022

Same author

The Prognostic Role of Metabolic and Endocrine Parameters for the Clinical Severity of COVID-19.

Disease markers·2022

Same author

Assessment of insulin resistance in patients with primary hyperparathyroidism before and after Parathyroidectomy.

Endocrinology, diabetes & metabolism·2021

Search research articles

Related Experiment Video

Updated: May 22, 2026

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Published on: December 26, 2017

Diabetic CVD--focus on vitamin D.

Shokoufeh Bonakdaran¹, Haleh Rokni

¹Mashhad University of Medical Science, Endocrine Research Center, Mashhad, Iran. bonakdaransh@mums.ac.ir

Cardiovascular & Hematological Agents in Medicinal Chemistry

|May 29, 2012

Summary

Vitamin D deficiency is common and impacts cardiovascular health, especially in diabetics. This review explores how vitamin D influences various cardiovascular disease risk factors.

Area of Science:

Endocrinology
Cardiology
Nutritional Science

Background:

Cardiovascular disease (CVD) is a major cause of death and illness in diabetic populations.
Vitamin D deficiency is globally prevalent and linked to metabolic syndrome and obesity.
Emerging evidence highlights vitamin D's crucial role in maintaining cardiovascular health.

Purpose of the Study:

To review the multifaceted impacts of vitamin D on cardiovascular disease risk factors.
To elucidate vitamin D's influence on metabolic syndrome components and obesity.
To examine vitamin D's effects on vascular function and inflammation.

Main Methods:

Literature review of studies investigating vitamin D and cardiovascular health.
Analysis of vitamin D's role in insulin regulation and the Renin-Angiotensin system.

Related Experiment Videos

Last Updated: May 22, 2026

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature

Published on: December 26, 2017

Examination of vitamin D's effects on vascular calcification and inflammatory markers.

Main Results:

Vitamin D deficiency is associated with increased prevalence of metabolic syndrome and obesity.
Vitamin D influences insulin secretion and action, benefiting cardiovascular health.
Vitamin D demonstrates protective effects against vascular calcification and inflammation.

Conclusions:

Vitamin D plays a significant role in modulating multiple cardiovascular disease risk factors.
Addressing vitamin D deficiency may offer a therapeutic strategy for cardiovascular risk reduction in susceptible populations.
Further research is warranted to fully understand vitamin D's cardiovascular benefits.